Walking-Related Dual-Task Interference in Early-to-Middle-Stage Huntington's Disease: An Auditory Event Related Potential Study.

ABSTRACT: Objective: To compare interference between walking and a simple P3 auditory odd-ball paradigm in patients with Huntington's disease (HD) and age- and sex-matched controls. Methods: Twenty-four early-to-middle-stage HD patients and 14 age- and sex-matched healthy volunteers were examined. EEG-EMG recordings were obtained from 21 scalp electrodes and eight bipolar derivations from the legs. Principal component analysis was used to obtain artifact-free recordings. The stimulation paradigm consisted of 50 rare and 150 frequent stimuli and was performed in two conditions: standing and walking along a 10 by 5 m path. P3 wave amplitude and latency and EEG and EMG spectral values were compared by group and experimental condition and correlated with clinical features of HD. Results

SUBMITTER: de Tommaso M 

PROVIDER: S-EPMC5535504 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature