Circulating levels of obesity-related markers and risk of renal cell carcinoma in the PLCO cancer screening trial.

ABSTRACT:

Purpose

Obesity is an established risk factor for renal cell carcinoma (RCC). It is unclear what biologic mechanisms underlie this association, although recent evidence suggests that the effects of circulating hormones such as insulin-like growth factors (IGF) and adipokines may play a role.

Methods

To address this question, we conducted a nested case-control study of RCC (252 cases, 252 controls) within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial investigating associations with pre-diagnostic serum levels of total adiponectin, high-molecular-weight (HMW) adiponectin, IGF-1, IGF-binding protein-3 (IGFBP-3), and C-peptide. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated using conditional logistic regression.

Results

After

SUBMITTER: Liao LM 

PROVIDER: S-EPMC5535804 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature