Associations of Drug Lipophilicity and Extent of Metabolism with Drug-Induced Liver Injury.

ABSTRACT: Drug-induced liver injury (DILI), although rare, is a frequent cause of adverse drug reactions resulting in warnings and withdrawals of numerous medications. Despite the research community's best efforts, current testing strategies aimed at identifying hepatotoxic drugs prior to human trials are not sufficiently powered to predict the complex mechanisms leading to DILI. In our previous studies, we demonstrated lipophilicity and dose to be associated with increased DILI risk and, and in our latest work, we factored reactive metabolites into the algorithm to predict DILI. Given the inconsistency in determining the potential for drugs to cause DILI, the present study comprehensively assesses the relationship between DILI risk and lipophilicity and the extent of metabolism using a large publis

SUBMITTER: McEuen K 

PROVIDER: S-EPMC5535828 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature