Entrainment of Breast Cell Lines Results in Rhythmic Fluctuations of MicroRNAs.

ABSTRACT: Circadian rhythms are essential for temporal (~24 h) regulation of molecular processes in diverse species. Dysregulation of circadian gene expression has been implicated in the pathogenesis of various disorders, including hypertension, diabetes, depression, and cancer. Recently, microRNAs (miRNAs) have been identified as critical modulators of gene expression post-transcriptionally, and perhaps involved in circadian clock architecture or their output functions. The aim of the present study is to explore the temporal expression of miRNAs among entrained breast cell lines. For this purpose, we evaluated the temporal (28 h) expression of 2006 miRNAs in MCF-10A, MCF-7, and MDA-MB-231 cells using microarrays after serum shock entrainment. We noted hundreds of miRNAs that exhibit rhythmic fluctu

SUBMITTER: Chacolla-Huaringa R 

PROVIDER: S-EPMC5535989 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature