The Interplay between the Host Receptor and Influenza Virus Hemagglutinin and Neuraminidase.

ABSTRACT: The hemagglutinin (HA) and neuraminidase (NA) glycoproteins of influenza A virus are responsible for the surface interactions of the virion with the host. Entry of the virus is mediated by functions of the HA: binding to cellular receptors and facilitating fusion of the virion membrane with the endosomal membrane. The HA structure contains receptor binding sites in the globular membrane distal head domains of the trimer, and the fusion machinery resides in the stem region. These sites have specific characteristics associated with subtype and host, and the differences often define species barriers. For example, avian viruses preferentially recognize α2,3-Sialic acid terminating glycans as receptors and mammalian viruses recognize α2,6-Sialic acid. The neuraminidase, or the receptor-destroyi

SUBMITTER: Byrd-Leotis L 

PROVIDER: S-EPMC5536029 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature