Ontology highlight
ABSTRACT:
SUBMITTER: Kuang H
PROVIDER: S-EPMC5536034 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Kuang Haixue H Tang Zhenqiu Z Zhang Chengyue C Wang Zhibin Z Li Wenji W Yang Chunjuan C Wang Qiuhong Q Yang Bingyou B Kong Ah-Ng AN
International journal of molecular sciences 20170717 7
Nuclear factor erythroid-2 related factor 2 (Nrf2) is a vital transcription factor that regulates the anti-oxidative defense system. Previous reports suggested that the expression of the <i>Nrf2</i> gene can be regulated by epigenetic modifications. The potential epigenetic effect of taxifolin (TAX), a potent cancer chemopreventive agent, in skin cancer chemoprotection is unknown. In this study, we investigated how Nrf2 is epigenetically regulated by TAX in JB6 P+ cells. TAX was found to inhibit ...[more]