The BDNF Val⁶⁶Met polymorphism is associated with structural neuroanatomical differences in young children.

ABSTRACT: The brain-derived neurotrophic factor (BDNF) Val⁶⁶Met single nucleotide polymorphism (SNP) has been associated with individual differences in brain structure and function, and cognition. Research on BDNF's influence on brain and cognition has largely been limited to adults, and little is known about the association of this gene, and specifically the Val⁶⁶Met polymorphism, with developing brain structure and emerging cognitive functions in children. We performed a targeted genetic association analysis on cortical thickness, surface area, and subcortical volume in 78 children (ages 6-10) who were Val homozygotes (homozygous Val/Val carriers) or Met carriers (Val/Met, Met/Met) for the Val⁶⁶Met locus using Atlas-based brain segmentation. We observed greater cor

SUBMITTER: Jasinska KK 

PROVIDER: S-EPMC5536104 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature