Persistence of circulating endothelial microparticles in COPD despite smoking cessation.

ABSTRACT:

Introduction

Increasing evidence links COPD pathogenesis with pulmonary capillary apoptosis. We previously demonstrated that plasma levels of circulating microparticles released from endothelial cells (EMPs) due to apoptosis are elevated in smokers with normal spirometry but low diffusion capacity, that is, with early evidence of lung destruction. We hypothesised that pulmonary capillary apoptosis persists with the development of COPD and assessed its reversibility in healthy smokers and COPD smokers following smoking cessation.

Methods

Pulmonary function and high-resolution CT (HRCT) were assessed in 28 non-smokers, 61 healthy smokers and 49 COPD smokers; 17 healthy smokers and 18 COPD smokers quit smoking for 12 months following the baseline visit. Total EMP (CD42b^-</

SUBMITTER: Strulovici-Barel Y 

PROVIDER: S-EPMC5536242 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature