Blood vessel tortuosity selects against evolution of aggressive tumor cells in confined tissue environments: A modeling approach.

ABSTRACT: Cancer is a disease of cellular regulation, often initiated by genetic mutation within cells, and leading to a heterogeneous cell population within tissues. In the competition for nutrients and growth space within the tumors the phenotype of each cell determines its success. Selection in this process is imposed by both the microenvironment (neighboring cells, extracellular matrix, and diffusing substances), and the whole of the organism through for example the blood supply. In this view, the development of tumor cells is in close interaction with their increasingly changing environment: the more cells can change, the more their environment will change. Furthermore, instabilities are also introduced on the organism level: blood supply can be blocked by increased tissue pressure or the tortu

SUBMITTER: Szabo A 

PROVIDER: S-EPMC5536454 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature