Association of VDR polymorphisms ( Taq I and Bsm I) with prostate cancer: a new meta-analysis.

ABSTRACT: Objective Prostate cancer is a malignant tumour that poses a serious risk to human health. Epidemiological studies suggest that it may be associated with vitamin D receptor gene ( VDR) polymorphisms. Previous work investigated potential risks between Taq I (rs731236) and Bsm I (rs1544410) VDR polymorphisms with prostate cancer in humans; however, results are inconsistent. Methods We conducted a meta-analysis to retrieve genetic association analyses of rs731236 and rs1544410 polymorphisms with prostate cancer from studies published between 2006-2016. Pooled odds ratios with 95% confidence intervals were used to assess genetic associations, and heterogeneity was assessed by Q and I²statistics. Results Our findings suggest a significant association between rs731236 and prostate can

SUBMITTER: Liu S 

PROVIDER: S-EPMC5536582 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature