Association between ECE1 gene polymorphisms and risk of intracerebral haemorrhage.

ABSTRACT:

Objective

To determine whether endothelin converting enzyme-1 (ECE1) gene polymorphisms contribute to susceptibility to intracerebral haemorrhage (ICH) by influencing blood pressure.

Methods

This case-control study enrolled patients with ICH and healthy control subjects from a Southern Han Chinese population. The ECE1 gene polymorphisms rs212528 and rs213045 were genotyped. The association between the genotypes and the risk of ICH was assessed. The effects of these two ECE1 gene polymorphisms on blood pressure were also analysed.

Results

A total of 389 patients with ICH and 404 healthy control subjects participated in the study. There was no significant association between the ECE1 rs212528 and rs213045 polymorphisms and ICH even after adjusting for different confound

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC5536701 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature