Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF.

ABSTRACT: Endothelial cells and leptin receptor⁺ (LepR⁺) stromal cells are critical sources of haematopoietic stem cell (HSC) niche factors, including stem cell factor (SCF), in bone marrow. After irradiation or chemotherapy, these cells are depleted while adipocytes become abundant. We discovered that bone marrow adipocytes synthesize SCF. They arise from Adipoq-Cre/ER⁺ progenitors, which represent ∼5% of LepR⁺ cells, and proliferate after irradiation. Scf deletion using Adipoq-Cre/ER inhibited haematopoietic regeneration after irradiation or 5-fluorouracil treatment, depleting HSCs and reducing mouse survival. Scf from LepR⁺ cells, but not endothelial, haematopoietic or osteoblastic cells, also promoted regeneration. In non-irradiated mice, Sc

SUBMITTER: Zhou BO 

PROVIDER: S-EPMC5536858 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature