Contributions of polygenic risk for obesity to PTSD-related metabolic syndrome and cortical thickness.

ABSTRACT:

Background

Research suggests that posttraumatic stress disorder (PTSD) is associated with metabolic syndrome (MetS) and that PTSD-associated MetS is related to decreased cortical thickness. However, the role of genetic factors in these associations is unclear. This study evaluated contributions of polygenic obesity risk and PTSD to MetS and of MetS and polygenic obesity risk to cortical thickness.

Methods

196 white, non-Hispanic veterans of the wars in Iraq and Afghanistan underwent clinical diagnostic interviews, physiological assessments, and genome-wide genotyping; 168 also completed magnetic resonance imaging scans. Polygenic risk scores (PRSs) for obesity were calculated from results of a prior genome-wide association study (Speliotes et al., 2010) and PTSD and MetS sev

SUBMITTER: Wolf EJ 

PROVIDER: S-EPMC5537007 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature