Associations Between Patient and Anthropometric Characteristics and Aromatase Inhibitor Discontinuation.

ABSTRACT:

Background

Toxicity can lead to noncontinuation of adjuvant endocrine therapy. We hypothesized that endocrine therapy-induced changes in grip strength would predict for early discontinuation of therapy because of musculoskeletal toxicity and would be associated with a patient's body mass index.

Patients and methods

Postmenopausal women with breast cancer starting a new adjuvant endocrine therapy were enrolled in the present study. The patients were monitored for 12 months to assess their symptoms, endocrine therapy adherence and change in grip strength and baseline body mass index. The association between the change in grip strength and interval to discontinuation was assessed using a joint longitudinal and survival model.

Results

Of the 93 aromatase inhibitor (AI)-tr

SUBMITTER: Henry NL 

PROVIDER: S-EPMC5537010 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature