Continued midazolam versus diphenhydramine in difficult-to-sedate patients: a randomized double-blind trial.

ABSTRACT:

Background and aims

Current guidelines recommend diphenhydramine in patients undergoing endoscopy who are not adequately sedated with a benzodiazepine and opioid combination. Because this practice has not been adequately assessed, we performed a randomized, double-blind trial comparing diphenhydramine with continued midazolam in such patients.

Methods

Patients undergoing elective colonoscopy with moderate sedation were eligible. Sedation was measured with the Modified Observer's Assessment of Alertness/Sedation (MOAA/S) score with adequate sedation defined as 3 on a 0- to 5-point scale. Patients not adequately sedated with midazolam 5 mg and fentanyl 100 μg were randomly assigned to diphenhydramine 25 mg versus continued midazolam 1.5 mg. Adequacy of sedation was assessed 3

SUBMITTER: Sachar H 

PROVIDER: S-EPMC5537051 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature