A CpG island methylator phenotype in acute myeloid leukemia independent of IDH mutations and associated with a favorable outcome.

ABSTRACT: Genetic changes are infrequent in acute myeloid leukemia (AML) compared with other malignancies and often involve epigenetic regulators, suggesting that an altered epigenome may underlie AML biology and outcomes. In 96 AML cases including 65 pilot samples selected for cured/not-cured, we found higher CpG island (CGI) promoter methylation in cured patients. Expanded genome-wide digital restriction enzyme analysis of methylation data revealed a CGI methylator phenotype independent of IDH1/2 mutations we term AML-CGI methylator phenotype (CIMP) (A-CIMP⁺). A-CIMP was associated with longer overall survival (OS) in this data set (median OS, years: A-CIMP⁺=not reached, CIMP^-=1.17; P=0.08). For validation we used 194 samples from The Cancer Genome Atlas interrogat

SUBMITTER: Kelly AD 

PROVIDER: S-EPMC5537054 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature