Association between CYP24A1 polymorphisms and the risk of colonic polyps and colon cancer in a Chinese population.

ABSTRACT:

Aim

To determine the pathogenesis and potential single nucleotide polymorphisms (SNPs) as screening sites for colonic polyps, colon cancer and ulcerative colitis, and to analyze the possible association between these genetic polymorphisms and the three diseases.

Methods

We evaluated genetic polymorphisms in 144 newly diagnosed colonic polyp patients, 96 colon cancer patients and 44 ulcerative colitis patients. The four SNPs genotyped were rs4809957, rs6068816, rs6091822 and rs8124792. The control group consisted of 504 East Asians enrolled in the 1000 Genomes Project. Correlations between CYP24A1 SNPs and the diseases were analyzed by Fisher's exact probability test.

Results

CYP24A1 polymorphisms rs4809957 A/G and rs6068816 C/T showed a statistically sig

SUBMITTER: Chen XQ 

PROVIDER: S-EPMC5537184 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature