Administration of Lactobacillus salivarius LI01 or Pediococcus pentosaceus LI05 prevents CCl₄-induced liver cirrhosis by protecting the intestinal barrier in rats.

ABSTRACT: Alterations in the gut microbiome have been reported in liver cirrhosis, and probiotic interventions are considered a potential treatment strategy. This study aimed to evaluate the effects and mechanisms of Lactobacillus salivarius LI01, Pediococcus pentosaceus LI05, Lactobacillus rhamnosus GG, Clostridium butyricum MIYAIRI and Bacillus licheniformis Zhengchangsheng on CCl₄-induced cirrhotic rats. Only administration of LI01 or LI05 prevented liver fibrosis and down-regulated the hepatic expression of profibrogenic genes. Serum endotoxins, bacterial translocations (BTs), and destruction of intestinal mucosal ultrastructure were reduced in rats treated with LI01 or LI05, indicating maintenance of the gut barrier as a mechanism; this was further confirmed by the reduction of not o

SUBMITTER: Shi D 

PROVIDER: S-EPMC5537250 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature