How gastrin-releasing peptide receptor (GRPR) and α_vβ₃ integrin expression reflect reorganization features of tumors after hyperthermia treatments.

ABSTRACT: The outcome of tumor treatment via hyperthermia in the clinic has been reported to be heterogeneous. Here, we assessed how the presence of gastrin-releasing peptide receptor (GRPR) and α_vβ₃ integrin together with the morphology of the vascularization reflects the growth behavior of tumors after hyperthermia treatment. MDA-MB-231 tumor bearing mice were treated either with high (46 °C) or low dose (42 °C) water hyperthermia for 60 min. Changes of GRPR and α_vβ₃ integrin expression were assessed via multiplexed optical imaging. Vascularization was reconstructed and quantified by µCT imaging after contrast agent injection. We found that high dose hyperthermia is capable of increasing the expression of GRPR, α_vβ₃ integrin, CD31,

SUBMITTER: Hallasch S 

PROVIDER: S-EPMC5537297 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature