Progesterone suppresses the invasion and migration of breast cancer cells irrespective of their progesterone receptor status - a short report.

ABSTRACT:

Purpose

Pre-operative progesterone treatment of breast cancer has been shown to confer survival benefits to patients independent of their progesterone receptor (PR) status. The underlying mechanism and the question whether such an effect can also be observed in PR negative breast cancer cells remain to be resolved.

Methods

We performed proteome profiling of PR-positive and PR-negative breast cancer cells in response to progesterone using a phospho-kinase array platform. Western blotting was used to validate the results. Cell-based phenotypic assays were conducted using PR-positive and PR-negative breast cancer cells to assess the effect of progesterone.

Results

We found that progesterone induces de-phosphorylation of 12 out of 43 kinases tested, which are mostly invol

SUBMITTER: Godbole M 

PROVIDER: S-EPMC5537311 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature