MicroRNA-371a-3p as informative biomarker for the follow-up of testicular germ cell cancer patients.

ABSTRACT:

Purpose

α-fetoprotein (AFP) and human chorionic gonadotropin subunit beta (B-HCG) are informative serum biomarkers for the primary diagnosis and follow-up of testicular germ cell cancer (TGCC) patients. About 20% of TGCC patients with a non-seminoma (NS) and about 80% with a seminoma (SE) are, however, negative for these biomarkers. Embryonic stem cell microRNAs (miRs) may serve as promising alternative serum biomarkers. Here we investigated a retrospective series of serum samples from selected TGCC patients who developed a relapse in time to test the possible additional value of the serum-based ampTSmiR test compared to the conventional serum-based protein biomarkers for follow-up.

Methods

We investigated 261 retrospective serum samples of six selected fully evaluated TGCC

SUBMITTER: van Agthoven T 

PROVIDER: S-EPMC5537315 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature