Oral squamous cell carcinoma patients can be differentiated from healthy individuals with label-free serum proteomics.

ABSTRACT:

Background

No blood biomarkers to detect early oral cavity squamous cell carcinoma (OSCC) without clinical signs exist - diagnosis is solely based on histology of a visible tumour. Most OSCC patients are diagnosed at advanced stage, which leads to significant morbidity and poor survival. Our aim was to find the serum screening or detection biomarkers in OSCC.

Methods

Serum samples from patients with OSCC treated at the Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital (Finland) were collected. Age- and gender-matched healthy individuals served as controls. Quantitative label-free proteomics in high definition MS^E mode(HDMS^E) was performed on 13 patients and 12 healthy samples. Various statistical analyses were perfo

SUBMITTER: Saraswat M 

PROVIDER: S-EPMC5537490 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature