Impact of novel miR-145-3p regulatory networks on survival in patients with castration-resistant prostate cancer.

ABSTRACT:

Background

Despite recent advancements, metastatic castration-resistant prostate cancer (CRPC) is not considered curative. Novel approaches for identification of therapeutic targets of CRPC are needed.

Methods

Next-generation sequencing revealed 945-1248 miRNAs from each lethal mCRPC sample. We constructed miRNA expression signatures of CRPC by comparing the expression of miRNAs between CRPC and normal prostate tissue or hormone-sensitive prostate cancer (HSPC). Genome-wide gene expression studies and in silico analyses were carried out to predict miRNA regulation and investigate the functional significance and clinical utility of the novel oncogenic pathways regulated by these miRNAs in prostate cancer (PCa).

Results

Based on the novel miRNA expression signature of C

SUBMITTER: Goto Y 

PROVIDER: S-EPMC5537499 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature