Chemotherapy with radiotherapy influences time-to-development of radiation-induced sarcomas: a multicenter study.

ABSTRACT:

Background

An increasing number and proportion of cancer patients with apparently localised disease are treated with chemotherapy and radiation therapy in contemporary oncology practice. In a pilot study of radiation-induced sarcoma (RIS) patients, we demonstrated that chemotherapy was associated with a reduced time to development of RIS. We now present a multi-centre collaborative study to validate this association.

Methods

This was a retrospective cohort study of RIS cases across five large international sarcoma centres between 1 January 2000 to 31 December 2014. The primary endpoint was time to development of RIS.

Results

We identified 419 patients with RIS. Chemotherapy for the first malignancy was associated with a shorter time to RIS development (HR 1.37; 95% CI

SUBMITTER: Zhang AY 

PROVIDER: S-EPMC5537501 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature