MRL proteins cooperate with activated Ras in glia to drive distinct oncogenic outcomes.

ABSTRACT: The Mig10/RIAM/Lpd (MRL) adapter protein Lpd regulates actin dynamics through interactions with Scar/WAVE and Ena/VASP proteins to promote the formation of cellular protrusions and to stimulate invasive migration. However, the ability of MRL proteins to interact with multiple actin regulators and to promote serum response factor (SRF) signalling has raised the question of whether MRL proteins employ alternative downstream mechanisms to drive oncogenic processes in a context-dependent manner. Here, using a Drosophila model, we show that overexpression of either human Lpd or its Drosophila orthologue Pico can promote growth and invasion of Ras^V12-induced cell tumours in the brain. Notably, effects were restricted to two populations of Repo-positive glial cells: an invasive populat

SUBMITTER: Taylor E 

PROVIDER: S-EPMC5537612 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature