Topologically convergent and divergent functional connectivity patterns in unmedicated unipolar depression and bipolar disorder.

ABSTRACT: Bipolar disorder (BD), particularly BD II, is frequently misdiagnosed as unipolar depression (UD), leading to inappropriate treatment and poor clinical outcomes. Although depressive symptoms may be expressed similarly in UD and BD, the similarities and differences in the architecture of brain functional networks between the two disorders are still unknown. In this study, we hypothesized that UD and BD II patients would show convergent and divergent patterns of disrupted topological organization of the functional connectome, especially in the default mode network (DMN) and the limbic network. Brain resting-state functional magnetic resonance imaging (fMRI) data were acquired from 32 UD-unmedicated patients, 31 unmedicated BD II patients (current episode depressed) and 43 healthy subjects. U

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5538109 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature