Unique prefrontal GABA and glutamate disturbances in co-occurring bipolar disorder and alcohol dependence.

ABSTRACT: Bipolar disorder (BD) and alcohol dependence (AD) frequently co-occur, and co-occurring BD and AD are associated with devastating public health costs. Minimal neurobiological research exists to guide the development of effective treatments for this treatment-resistant population. We believe the present study represents the first investigation of prefrontal gamma-aminobutyric acid (GABA) and glutamate levels in co-occurring BD and current AD. The participants were 78 individuals who met DSM-IV criteria for BD I/II and current AD (n=20), BD I/II alone (n=19), current AD alone (n=20) or no diagnosis (n=19). The participants completed a baseline diagnostic visit, then returned approximately 4 days later for a two-dimensional J-resolved proton magnetic resonance spectroscopy (¹H-MRS)

SUBMITTER: Prisciandaro JJ 

PROVIDER: S-EPMC5538121 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature