Longitudinal changes in glucocorticoid receptor exon 1_F methylation and psychopathology after military deployment.

ABSTRACT: Several cross-sectional studies have demonstrated the relevance of DNA methylation of the glucocorticoid receptor exon 1_F region (GR-1_F) for trauma-related psychopathology. We conducted a longitudinal study to examine GR-1_F methylation changes over time in relation to trauma exposure and the development of post-deployment psychopathology. GR-1_F methylation (52 loci) was quantified using pyrosequencing in whole blood of 92 military men 1 month before and 6 months after a 4-month deployment period to Afghanistan. GR-1_F methylation overall (mean methylation and the number of methylated loci) and functional methylation (methylation at loci associated with GR exon 1_F expression) measures were examined. We first investigated the e

SUBMITTER: Schur RR 

PROVIDER: S-EPMC5538126 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature