Association of Triglyceride-Related Genetic Variants With Mitral Annular Calcification.

ABSTRACT:

Background

Mitral annular calcium (MAC), commonly identified by cardiac imaging, is associated with cardiovascular events and predisposes to the development of clinically important mitral valve regurgitation and mitral valve stenosis. However, its biological determinants remain largely unknown.

Objectives

The authors sought to evaluate whether a genetic predisposition to elevations in plasma lipids is associated with the presence of MAC.

Methods

The authors used 3 separate Mendelian randomization techniques to evaluate the associations of lipid genetic risk scores (GRS) with MAC in 3 large patient cohorts: the Framingham Health Study, MESA (Multiethnic European Study of Atherosclerosis), and the AGE-RS (Age, Gene/Environment Susceptibility-Reykjavik Study). The author

SUBMITTER: Afshar M 

PROVIDER: S-EPMC5538134 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature