Mechanisms underlying vestibulo-cerebellar motor learning in mice depend on movement direction.

ABSTRACT:

Key points

Directionality, inherent to movements, has behavioural and neuronal correlates. Direction of vestibular stimulation determines motor learning efficiency. Vestibulo-ocular reflex gain-increase correlates with Purkinje cell simple spike potentiation. The locus of neural correlates for vestibulo-ocular reflex adaptation is paradigm specific.

Abstract

Compensatory eye movements elicited by head rotation, also known as vestibulo-ocular reflex (VOR), can be adapted with the use of visual feedback. The cerebellum is essential for this type of movement adaptation, although its neuronal correlates remain to be clarified. In the present study, we show that the direction of vestibular input determines the magnitude of eye movement adaptation induced by mismatched visual inpu

SUBMITTER: Voges K 

PROVIDER: S-EPMC5538199 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature