Tumor accumulation of liposomal doxorubicin in three murine models: Optimizing delivery efficiency.

ABSTRACT: Systemic drug delivery to a solid tumor involves a sequence of steps that determine efficacy and survival. Extravasation from circulation at the tumor site is a critical step in this sequence since it regulates how much of the drug accumulates in the tumor. Despite its importance in determining outcomes, extravasation from circulation remains a "black box." The objective of this study is to develop predictive tools for optimization of drug delivery systems. By comparing pharmacokinetics of liposomal doxorubicin in tumor-free and tumor bearing mice we quantitatively assess the rate constants for distribution, elimination, and tumor accumulation. We then relate these rate constants to the tumor-type and drug delivery system. We compare tumor accumulation in three tumor types and show a 10-fo

SUBMITTER: Dawidczyk CM 

PROVIDER: S-EPMC5538251 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature