Comprehensive definition of human immunodominant CD8 antigens in tuberculosis.

ABSTRACT: Despite widespread use of the Bacillus Calmette-Guerin vaccine, tuberculosis, caused by infection with Mycobacterium tuberculosis, remains a leading cause of morbidity and mortality worldwide. As CD8⁺ T cells are critical to tuberculosis host defense and a phase 2b vaccine trial of modified vaccinia Ankara expressing Ag85a that failed to demonstrate efficacy, also failed to induce a CD8⁺ T cell response, an effective tuberculosis vaccine may need to induce CD8⁺ T cells. However, little is known about CD8, as compared to CD4, antigens in tuberculosis. Herein, we report the results of the first ever HLA allele independent genome-wide CD8 antigen discovery program. Using CD8⁺ T cells derived from humans with latent tuberculosis infection or t

SUBMITTER: Lewinsohn DA 

PROVIDER: S-EPMC5538316 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature