Central noradrenaline transporter availability in highly obese, non-depressed individuals.

ABSTRACT:

Purpose

The brain noradrenaline (NA) system plays an important role in the central nervous control of energy balance and is thus implicated in the pathogenesis of obesity. The specific processes modulated by this neurotransmitter which lead to obesity and overeating are still a matter of debate.

Methods

We tested the hypothesis that in vivo NA transporter (NAT) availability is changed in obesity by using positron emission tomography (PET) and S,S-[¹¹C]O-methylreboxetine (MRB) in twenty subjects comprising ten highly obese (body mass index BMI > 35 kg/m²), metabolically healthy, non-depressed individuals and ten non-obese (BMI < 30 kg/m²) healthy controls.

Results

Overall, we found no significant differences in binding potential (BP

SUBMITTER: Hesse S 

PROVIDER: S-EPMC5538358 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature