Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia.

ABSTRACT:

Objective

To examine the association between genetic predisposition to elevated C-reactive protein (CRP)and risk for preeclampsia using validated genetic loci for C-reactive protein.

Methods

Preeclampsia cases (n = 177) and normotensive controls (n = 116) were selected from live birth certificates to nulliparous Iowa women during the period August 2002-May 2005. Disease status was verified by the medical chart review. Genetic predisposition to CRP was estimated by a genetic risk score on the basis of established loci for CRP levels. Logistic regression analyses were used to evaluate the relationships between the genotype score and preeclampsia. Replication analyses were performed in an independent, US population of preeclampsia cases (n = 516) and controls (n = 1,097) of Eur

SUBMITTER: Spracklen CN 

PROVIDER: S-EPMC5538572 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature