Gestational diabetes mellitus and interpregnancy weight change: A population-based cohort study.

ABSTRACT:

Background

Being overweight is an important risk factor for Gestational Diabetes Mellitus (GDM), but the underlying mechanisms are not understood. Weight change between pregnancies has been suggested to be an independent mechanism behind GDM. We assessed the risk for GDM in second pregnancy by change in Body Mass Index (BMI) from first to second pregnancy and whether BMI and gestational weight gain modified the risk.

Methods and findings

In this observational cohort, we included 24,198 mothers and their 2 first pregnancies in data from the Medical Birth Registry of Norway (2006-2014). Weight change, defined as prepregnant BMI in second pregnancy minus prepregnant BMI in first pregnancy, was divided into 6 categories by units BMI (kilo/square meter). Relative risk (RR) estima

SUBMITTER: Sorbye LM 

PROVIDER: S-EPMC5538633 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature