Ontology highlight
ABSTRACT:
SUBMITTER: Claus S
PROVIDER: S-EPMC5538634 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
EMBO reports 20170621 8
Serum amyloid A1 (SAA1) is an apolipoprotein that binds to the high-density lipoprotein (HDL) fraction of the serum and constitutes the fibril precursor protein in systemic AA amyloidosis. We here show that HDL binding blocks fibril formation from soluble SAA1 protein, whereas internalization into mononuclear phagocytes leads to the formation of amyloid. SAA1 aggregation in the cell model disturbs the integrity of vesicular membranes and leads to lysosomal leakage and apoptotic death. The formed ...[more]