Antiretroviral resistance following immunological monitoring in a resource-limited setting of western India: A cross-sectional study.

ABSTRACT:

Background

The free antiretroviral therapy (ART) program in India still relies on the clinico-immunological monitoring for diagnosis of treatment failure. As the nucleoside reverse transcriptase inhibitor (NRTI) backbone is shared in first- and second-line regimens, accumulation of drug resistant mutations (DRMs) can compromise the efficacy of NRTI. This study was undertaken to describe the pattern of HIV DRMs following immunological monitoring and investigate its impact on the cycling of NRTI between first- and second-line ART.

Methods and findings

This cross-sectional study was performed at a state-sponsored ART clinic of Pune city in western India between January and June 2016. Consecutive adults receiving first-line ART with immunological failure (IF) were recruited for

SUBMITTER: Karade SK 

PROVIDER: S-EPMC5538665 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature