Expression and localization of VPAC1, the major receptor of vasoactive intestinal peptide along the length of the intestine.

ABSTRACT: Vasoactive intestinal peptide (VIP) is an endogenous neuropeptide with a broad array of physiological functions in many organs including the intestine. Its actions are mediated via G protein-coupled receptors, and vasoactive intestinal peptide receptor 1 (VPAC1) is the key receptor responsible for majority of VIP's biological activity. The distribution of VPAC1 along the length of the gastrointestinal tract and its subcellular localization in intestinal epithelial cells have not been fully characterized. The current studies were undertaken to determine VPAC1 distribution and localization so that VIP-based therapies can be targeted to specific regions of the intestine. The results indicated that the mRNA levels of VPAC1 showed an abundance pattern of colon > ileum > jejunum in the mouse int

SUBMITTER: Jayawardena D 

PROVIDER: S-EPMC5538834 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature