Morbidity and mortality among exclusively breastfed neonates with medium-chain acyl-CoA dehydrogenase deficiency.

ABSTRACT:

Purpose

Despite greatly improved morbidity and mortality among infants with medium-chain acyl-CoA dehydrogenase deficiency (MCAD) since the implementation of universal newborn screening (NBS), a population of neonates still becomes ill before their positive screen results are available. Exclusive breastfeeding is a proposed risk factor in this group. Since initial studies of MCAD NBS, breastfeeding rates have increased substantially. In this study, we quantify the current risk of early decompensation in neonates with MCAD and identify factors associated with poor outcomes.

Methods

We completed a retrospective analysis of neonates with MCAD referred to our center between 2010 and 2015.

Results

Of 46 infants with MCAD, 11 (23.9%) were symptomatic before the return of th

SUBMITTER: Ahrens-Nicklas RC 

PROVIDER: S-EPMC5538896 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature