Impact of membrane lung surface area and blood flow on extracorporeal CO₂ removal during severe respiratory acidosis.

ABSTRACT:

Background

Veno-venous extracorporeal CO₂ removal (vv-ECCO₂R) is increasingly being used in the setting of acute respiratory failure. Blood flow rates through the device range from 200 ml/min to more than 1500 ml/min, and the membrane surface areas range from 0.35 to 1.3 m². The present study in an animal model with similar CO₂ production as an adult patient was aimed at determining the optimal membrane lung surface area and technical requirements for successful vv-ECCO₂R.

Methods

Four different membrane lungs, with varying lung surface areas of 0.4, 0.8, 1.0, and 1.3m² were used to perform vv-ECCO₂R in seven anesthetized, mechanically ventilated, pigs with experimentally induced severe respiratory

SUBMITTER: Karagiannidis C 

PROVIDER: S-EPMC5539069 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature