Quantitative Proteomics of Cerebrospinal Fluid in Paediatric Pneumococcal Meningitis.

ABSTRACT: Streptococcus pneumoniae is responsible for diseases causing major global public health problems, including meningitis, pneumonia and septicaemia. Despite recent advances in antimicrobial therapy, pneumococcal meningitis remains a life-threatening disease. Furthermore, long-term sequelae are a major concern for survivors. Hence, a better understanding of the processes occurring in the central nervous system is crucial to the development of more effective management strategies. We used mass spectrometry based quantitative proteomics to identify protein changes in cerebrospinal fluid from children with Streptococcus pneumoniae infection, compared with children admitted to hospital with bacterial meningitis symptoms but negative diagnosis. Samples were analysed, by label free proteomics, in t

SUBMITTER: Gomez-Baena G 

PROVIDER: S-EPMC5539295 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature