NKG2C⁺ memory-like NK cells contribute to the control of HIV viremia during primary infection: Optiprim-ANRS 147.

ABSTRACT: Natural-killer (NK) cells are important immune effectors during a viral infection. Latent CMV infection is widely spread and was demonstrated to shape the NK cell repertoire through the NKG2C receptor. An expansion of NKG2C⁺ NK cells has been reported during primary HIV infection (PHI), but their role is not known. We previously found a correlation between the maturation state of the NK cell compartment and a lower viral load by studying patients from the ANRS 147 Optiprim trial. We investigated here extensively the NKG2C⁺ NK cells at the time of PHI and its evolution after 3 months of early antiretroviral therapy (combination antiretroviral therapy (cART)). Multiparametric cytometry combined with bioinformatics was used to determine subsets. NK^bright NKG2C

SUBMITTER: Gondois-Rey F 

PROVIDER: S-EPMC5539415 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature