Transdiagnostic Associations Between Functional Brain Network Integrity and Cognition.

ABSTRACT:

Importance

Cognitive impairment occurs across the psychosis spectrum and is associated with functional outcome. However, it is unknown whether these shared manifestations of cognitive dysfunction across diagnostic categories also reflect shared neurobiological mechanisms or whether the source of impairment differs.

Objective

To examine whether the general cognitive deficit observed across psychotic disorders is similarly associated with functional integrity of 2 brain networks widely implicated in supporting many cognitive domains.

Design, setting, and participants

A total of 201 healthy control participants and 375 patients with psychotic disorders from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium were studied from September 29, 20

SUBMITTER: Sheffield JM 

PROVIDER: S-EPMC5539843 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature