Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor.

ABSTRACT: Coenzyme Q (Q) is a lipid-soluble antioxidant essential in cellular physiology. Patients with Q deficiencies, with few exceptions, seldom respond to treatment. Current therapies rely on dietary supplementation with Q₁₀, but due to its highly lipophilic nature, Q₁₀ is difficult to absorb by tissues and cells. Plant polyphenols, present in the human diet, are redox active and modulate numerous cellular pathways. In the present study, we tested whether treatment with polyphenols affected the content or biosynthesis of Q. Mouse kidney proximal tubule epithelial (Tkpts) cells and human embryonic kidney cells 293 (HEK 293) were treated with several types of polyphenols, and kaempferol produced the largest increase in Q levels. Experiments with stable isotope ¹³C-

SUBMITTER: Fernandez-Del-Rio L 

PROVIDER: S-EPMC5539908 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature