Assessment of genetic polymorphisms associated with hyperuricemia or gout in the Hmong.

ABSTRACT:

Aim

Hyperuricemia commonly causes gout. Minnesota Hmong exhibit a two- to fivefold higher prevalence of gout versus non-Hmong. To elucidate a possible genomic contribution to this disparity, prevalence of risk alleles for hyperuricemia in Hmong was compared with European (CEU) and Han-Chinese (CHB).

Methods

In total, 235 Hmong were genotyped for eight SNPs representing five candidate genes (SLC22A12, SLC2A9, ABCG2, SLC17A1 and PDZK1).

Results

The frequency of seven out of eight risk alleles in the Hmong was significantly different than CEU; six higher and one with lower prevalence. The frequency of three out of eight risk alleles in the Hmong was significantly different than CHB; two higher and one with lower prevalence.

Conclusio

SUBMITTER: Roman YM 

PROVIDER: S-EPMC5539965 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature