Association of Gastric Acid Suppression With Recurrent Clostridium difficile Infection: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Gastric acid suppression has been associated with an increased risk of primary Clostridium difficile infection (CDI), but the risk of recurrent CDI in patients taking gastric acid suppressant medications is unclear.

Objective

To perform a systematic review and meta-analysis to evaluate the association between gastric acid suppressants and recurrent CDI.

Data sources

MEDLINE, EMBASE, the Cochrane Central Register, the Cochrane Database, and Web of Science were searched from January 1, 1995, to September 30, 2015, for studies assessing the association between gastric acid suppressant exposure and recurrent CDI. Search terms included Clostridium difficile, pseudomembranous colitis, proton pump inhibitor, and histamine H2 blocker.

Study selection

Case-co

SUBMITTER: Tariq R 

PROVIDER: S-EPMC5540201 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature