Polyfluoroalkyl substance exposure in the Mid-Ohio River Valley, 1991-2012.

ABSTRACT:

Background

Industrial discharges of perfluorooctanoic acid (PFOA) to the Ohio River, contaminating water systems near Parkersburg, WV, were previously associated with nearby residents' serum PFOA concentrations above US general population medians. Ohio River PFOA concentrations downstream are elevated, suggesting Mid-Ohio River Valley residents are exposed through drinking water.

Objectives

Quantify PFOA and 10 other per- and polyfluoroalkyl substances (PFAS) in Mid-Ohio River Valley resident sera collected between 1991 and 2013 and determine whether the Ohio River and Ohio River Aquifer are exposure sources.

Methods

We measured eleven PFAS in 1608 sera from 931 participants. Serum PFOA concentration and water source associations were assessed using linear mixed-effec

SUBMITTER: Herrick RL 

PROVIDER: S-EPMC5540235 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature