Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies.

ABSTRACT:

Objective

To determine the risk of pre-eclampsia associated with factors that may be present at antenatal booking.

Design

Systematic review of controlled studies published 1966-2002.

Data synthesis

Unadjusted relative risks were calculated from published data.

Results

Controlled cohort studies showed that the risk of pre-eclampsia is increased in women with a previous history of pre-eclampsia (relative risk 7.19, 95% confidence interval 5.85 to 8.83) and in those with antiphospholipids antibodies (9.72, 4.34 to 21.75), pre-existing diabetes (3.56, 2.54 to 4.99), multiple (twin) pregnancy (2.93, 2.04 to 4.21), nulliparity (2.91, 1.28 to 6.61), family history (2.90, 1.70 to 4.93), raised blood pressure (diastolic > or = 80 mm Hg) at booking (1.38, 1.01 to 1.87),

SUBMITTER: Duckitt K 

PROVIDER: S-EPMC554027 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature