Systematic review and meta-analysis of proton pump inhibitor therapy in peptic ulcer bleeding.

ABSTRACT:

Objectives

To review randomised controlled trials of treatment with a proton pump inhibitor in patients with ulcer bleeding and determine the impact on mortality, rebleeding, and surgical intervention.

Design

Systematic review and meta-analysis.

Data sources

Cochrane Collaboration's trials register, Medline, and Embase, handsearched abstracts, and pharmaceutical companies.

Review methods

Included randomised controlled trials compared proton pump inhibitor with placebo or H2 receptor antagonist in endoscopically proved bleeding ulcer and reported at least one of mortality, rebleeding, or surgical intervention. Trials were graded for methodological quality. Two assessors independently reviewed each trial, and disagreements were resolved by consensus.

Results</

SUBMITTER: Leontiadis GI 

PROVIDER: S-EPMC554028 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature