Bacteriophage evolution differs by host, lifestyle and genome.

ABSTRACT: Bacteriophages play key roles in microbial evolution^1,2, marine nutrient cycling³ and human disease⁴. Phages are genetically diverse, and their genome architectures are characteristically mosaic, driven by horizontal gene transfer with other phages and host genomes⁵. As a consequence, phage evolution is complex and their genomes are composed of genes with distinct and varied evolutionary histories^6,7. However, there are conflicting perspectives on the roles of mosaicism and the extent to which it generates a spectrum of genome diversity⁸ or genetically discrete populations^9,10. Here, we show that bacteriophages evolve within two general evolutionary modes that differ in the extent of horizontal gene transfer by an

SUBMITTER: Mavrich TN 

PROVIDER: S-EPMC5540316 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature